Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa
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Corrigendum: Tea polyphenols as an antivirulence compound Disrupt Quorum-Sensing Regulated Pathogenicity of Pseudomonas aeruginosa
The original version of this Article contained a typographical error in the spelling of the author Hongping Yin, which was incorrectly given as Honging Yin. This has now been corrected in the PDF and HTML versions of the Article. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the arti...
متن کاملTea polyphenols as an antivirulence compound Disrupt Quorum-Sensing Regulated Pathogenicity of Pseudomonas aeruginosa
Green tea, a water extract of non-fermented leaves of Camellia sinensis L., is one of the nonalcoholic beverages in China. It is becoming increasingly popular worldwide, because of its refreshing, mild stimulant and medicinal properties. Here we examined the quorum sensing inhibitory potentials of tea polyphenols (TP) as antivirulence compounds both in vitro and in vivo. Biosensor assay data su...
متن کاملIdentification of genes controlled by quorum sensing in Pseudomonas aeruginosa.
Bacteria communicate with each other to coordinate expression of specific genes in a cell density-dependent fashion, a phenomenon called quorum sensing and response. Although we know that quorum sensing via acyl-homoserine lactone (HSL) signals controls expression of several virulence genes in the human pathogen Pseudomonas aeruginosa, the number and types of genes controlled by quorum sensing ...
متن کاملQuorum Sensing Inhibitors as Anti-Pathogenic Drugs in the Fight Against Pseudomonas aeruginosa Infections
The increasing of antibiotic resistance among clinically P. aeruginosa strains determined researchers to find out new alternatives to antibiotic treatment. The newest strategy in therapeutics development is represented by an alternative approach which aims to target functions essential for infection, such as virulence factors required to cause host damage and disease. This approach has several ...
متن کاملRepurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa
BACKGROUND Quorum sensing is a mechanism of intercellular communication that controls the production of virulence factors in Pseudomonas aeruginosa. Inhibition of quorum sensing can disarm the virulence factors without exerting stress on bacterial growth that leads to emergence of antibiotic resistance. OBJECTIVES Finding a new quorum sensing inhibitor and determining its inhibitory activitie...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2018
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01296-18